Polpharma's annual capacity is aproxximately 200 m drug packages. In one of the largest and most modern drug manufacturing plants in Europe, the company manufactures solid drug forms, such as tablets, film-coated tablets, effervescent tablets, sugar coated tablets, and capsules. The annual manufacturing capacity of solid forms is 6 billion units. A fully hermetic manufacturing process allows the protection from any possible contamination and protects employees from contact with chemicals.

Polpharma also manufactures parenteral drugs, injectable preparations in polyethyl­ene packagings and glass ampoules, single- and multi-dose eye drops, nasal drops, infusion fluids, and fluids for external use. In 2005, the company started manufacturing in the new ampoule filling facility, which was constructed in compliance with the strictest cGMP standards for sterile manufacturing.